I was born in 1981 in Nicosia, Cyprus. After graduating from Güzelyurt Turkish Maarif College in 1998, I graduated from Istanbul Medical Faculty in 2004. In 2010, I completed my obstetrics and gynecology residency in Istanbul Medical Faculty, Department of Obstetrics and I started my working life. I continued my studies on infertility, which is my special interest, at Istanbul Memorial IVF Center. I completed the Ministry of Health IVF certification program at the same center. Since 2014, I have been continuing my professional life as the director of Cyprus Gynolife IVF Center. Our center operates within the body of Cyprus Life Hospital, which is the first private hospital of Northern Cyprus. Since the day it was founded, we have been following the latest scientific developments by prioritizing ethical values. We aim at high pregnancy rates with our embryology laboratory equipped with advanced technology, which is the most important building block of the IVF center.
IVF is a treatment option developed for couples who cannot conceive naturally. In IVF treatment, a woman's eggs are grown and developed using hormone drugs. These are combined with sperm using laboratory techniques and the pre-formation of the baby, called an embryo, is formed. Embryos are then transferred to the mother's womb.
Embryos are followed in special cabinets called incubators in the laboratory. Predetermined levels of pH, heat and gas are provided within the incubators, which are important for growth. In the follow-up of embryo development, embryologists check the cell number/development rate and quality at regular intervals.
In vitro fertilization treatment is applied to those who have egg factor, those with tube blockage, problems in sperm or those who cannot achieve pregnancy with other simple treatments.
Microinjection has been used successfully for years in the process of combining egg and sperm. In this process, the sperm is taken and put into the egg with the help of an injector. In this process, the process of magnifying the image of the sperm by 6000 times and keeping the morphology in the foreground is called IMSI (intracytoplasmic morphological sperm injection). It can be used in recurrent IVF failure or in those with severe sperm deformity.
Embryo genetic structure cannot be understood from the outside. For this, Preimplantation genetic diagnosis (PGD) is performed to evaluate the genetic structure. For PGD, cells are obtained from the embryo by a process called biopsy. Biopsy can be performed on the first, third or fifth days of the embryo. In recent years, 5th day biopsy, namely trophectoderm biopsy, is frequently preferred because it does not harm the embryo and has high accurate diagnosis rates. By evaluating the genetic structure, the chromosomal structure of the embryo or genetic diseases can be evaluated.
Egg freezing is a method that has become popular in recent years. Egg quality declines with advancing female age. For this reason, women who are not planning a pregnancy yet freeze their eggs in order to achieve pregnancy with IVF treatment in the future. Eggs obtained through IVF treatment are frozen and stored. In this way, when the woman plans pregnancy, the eggs are dissolved and combined with the sperm and embryos are formed. The chance of pregnancy will be equal to the chance of success at the age at which the woman had her eggs collected.
It is possible to provide egg development with the help of some pills in suitable patients, which is called mini in vitro fertilization. In this way, less hormones will be given to the body and better quality eggs will be obtained.
The most important criterion affecting the success of IVF treatment is the age of the woman. With advancing age, deterioration in egg quality and genetic structure occurs. And the number of healthy eggs is decreasing. Other factors besides the age of the woman, the number of eggs of the woman, the quality of the sperm and the anatomical structure of the woman should be evaluated. The pregnancy rate in a young woman (under 35 years old) is between 55-60%. However, around the age of 40, this rate drops to 30%, and after the age of 43, it drops below 5%.
When choosing an IVF center, it should be prioritized whether the center adheres to ethical values, the doctor's education, interest and skills, the technical equipment of the laboratory, and pregnancy rates.
Those who are considering IVF treatment should first go through a detailed examination and necessary tests. Both men and women should be examined in terms of problems, appropriate treatment should be planned, and treatment should be started at the most appropriate time.
When should genetic diagnosis be considered in the embryo? In which cases genetic diagnosis can be made?
The process called PGT can be done in various situations. Evaluation of the chromosomal structure of the embryo and/or gene diseases can be evaluated. Conditions that require evaluation of the chromosomal structure of the embryo include advanced female age, a carrier of a chromosomal disease in either of the husband and wife. Gene diseases such as thalassemia, sickle cell anemia and many other rare diseases that can be seen frequently in our country can be investigated by this method. With PGD, healthy embryos can be obtained and a healthy baby can be obtained.
What are the anatomical/structural problems of women in IVF treatment? How do they cause failure? What are the treatments?
Any structural problem caused by the woman can have a negative effect on conception. Problems in the uterus or tubes are important. It can be diagnosed with ultrasound or uterine film (HSG-hysterosalpingography). In case of any obstruction in the tubes, it will be impossible to achieve pregnancy by natural means. For this reason, IVF treatment is recommended for such a couple at the first stage. Congenital closure of the tubes can be seen, but mostly due to previous surgeries or infections. In some cases, there may be fluid collection in the tubes, namely hydrosalpenx. The hydrosalpenx shows us that the tube structure has deteriorated, the only treatment for this is removal or closure of the tube. This is done with a closed surgery called laparoscopy. It is thought that opening the tubes when a damage is detected will increase the risk of ectopic pregnancy in the future. Therefore, disconnecting the damaged tube from the uterus is the appropriate solution. In the uterus, there may be septum, stenosis, deformity, polyps, fibroids or adhesions. It can prevent the embryo from adhering both naturally and in IVF treatment. For this, with a procedure called hysteroscopy, the uterus can be looked at with a light camera and necessary treatment can be performed.